Abstract by Nathan Humphries
Chemistry and Biochemistry
Selective Binding of 3-Dimensional DNA Origami to Patterned Gold Surfaces.
DNA origami is a novel approach to bottom-up fabrication of electronic parts at the nanoscale for use in the computer chip industry. Single stranded DNA will pair with small synthetic “staple” strands of DNA, which constrain the strand of DNA to specific conformations. This DNA folding technique, now known as DNA origami, is a reliable way to create 2D patterns and 3D designs. These structures can be used as a scaffold for the precise placement of inorganic materials including carbon nanotubes and metal nanoparticles. which can be grown into nanowires with controllable dimensions and less than 10 nm linewidths. One important step in this self-assembly method is the selective placement of DNA origami at the nanoscale which is essential for application of this technology. 5 nm gold nanoparticles were functionalized with short DNA sequences that bind to corresponding strands on origami structures. Using this DNA based binding method, DNA origami can be shown to preferentially bind to the gold nanostructures over an inert mica surface.