Abstract by Eddie Sai Lun Lee
Eddie Sai Lun Lee
Chemistry and Biochemistry
The Interaction of Capillary Morphogenesis Gene 2 (CMG2) and Extracellular Cellular Matrix (ECM)
CMG2 has been identified as a regulator of angiogenesis. Our lab and others have suggested that CMG2 interacts with ECM proteins, and these CMG2– ECM interactions may play a critical role in mediating angiogenesis. Like its only known homolog, TEM8, we have shown that CMG2 not only binds to ECM but also has a key role in cell adhesion and spreading. We have also identified specific regions of ECM that bind to CMG2 using peptide arrays. We have identified peptides from ECM that bind CMG2 for the majority of ECM proteins in the basement membrane. Together, these findings begin to elucidate the role of CMG2 in angiogenesis.