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Abstract by Brooke Brady

Personal Infomation


Presenter's Name

Brooke Brady

Co-Presenters

Stefannia Esparza

Degree Level

Undergraduate

Abstract Infomation


Department

Chemistry and Biochemistry

Faculty Advisor

Pam Van Ry

Title

Idiopathic pulmonary fibrosis

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease, in which the lung tissue scares and deteriorates over time. Research shows, IPF patients have a known correlation of decreased relaxin family peptide receptor-1 (RXFP1) in the lung tissue, as well as a high prevalence of gastroesophageal reflux (GER). The relationship between GER and RXFP1 is yet to be tested or understood. Our hypothesis is that chronic GER initiates aberrant wound healing that is accelerated by the low expression of RXFP1. First, we plan to determine the role GRE and RXFP1 plays in exacerbation of lung fibrosis through quantification of cell proliferation, and differentiation assays using non-diseased and IPF human lung fibroblast. Second, we will determine if lung fibroblasts lacking RXFP1, subjected to chronic conditions of GRE in vitro, develop fibrosis at a higher rate than those with basal levels of RXFP1. Our goal is to understand the link between GRE and RXFP1 expression, and provide a way to decrease the rate of fibrotic progression in IPF patients.