Abstract by Colton Crowther
Chemistry and Biochemistry
Esterified Analogs of Resveratrol
Resveratrol is a natural polyphenol found in grapes, various berries, peanuts, and Japanese knotweed that has been discovered to be a putative, non-toxic therapeutic agent in combating diabetes, cardiovascular disease, and cancer. Our hypothesis is that we can synthetically modify Resveratrol and that these modifications will increase its bioactivity and availability in an organism. We have developed an analog (pivalic ester at the 4’ position) that has already shown to induce significantly larger reductions in cell viability that Resveratrol itself. Currently our research has involved producing more of the pivalated ester product as well as developing other esterified analogs to be screened.